Ketamine Inside Neurons?

Nicotine inside neurons

Tobacco smoking is a major source of preventable morbidity and mortality worldwide particularly due to lung tumours and/or cardiovascular pathologies. Continued tobacco smoking is primarily driven by dependence on nicotine, one of the main psychoactive ingredients of tobacco smoke, which initiates a series of adaptive changes in brain neurons and circuits by binding with high affinity to neuron...

Ketamine stereoselectively inhibits spontaneous Ca2+-oscillations in cultured hippocampal neurons.

Spontaneous Ca2+-oscillations are a result of periodic increases and decreases of cytosolic Ca2+. In neurons, they are thought to possess integrative properties because amplitude and frequency influence axon outgrowth, neuronal growth cone migration, and long distant wiring within the developing cortex. Ketamine stereoisomers differ in their affinities for the N-methyl-D-aspartic acid receptor ...

Anesthetic efficacy of ketamine, ketamine-tramadol and ketamine-ketorolac in chicks

Background: Ketamine produces ordinary general anesthesia characterized by weak hypnosis and analgesia leading to complications during surgical operations. Aims: The aim of this study was to evaluate the combination of ketorolac or tramadol to enhance ketamine anesthesia in 7 to 20-day-old chicks and its feasibility and practical application for induction of ge...

[Ketamine].

Ketamine Causes Mitochondrial Dysfunction in Human Induced Pluripotent Stem Cell-Derived Neurons

PURPOSE Ketamine toxicity has been demonstrated in nonhuman mammalian neurons. To study the toxic effect of ketamine on human neurons, an experimental model of cultured neurons from human induced pluripotent stem cells (iPSCs) was examined, and the mechanism of its toxicity was investigated. METHODS Human iPSC-derived dopaminergic neurons were treated with 0, 20, 100 or 500 μM ketamine for 6 ...